National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Exploring the chelating action of chito-oligosacchrides on bromate salt in aging rats.

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1.        Period covered by the research: the answer is 2, 2 what?

2.        How was the sample size calculated to justify 30 rats, 10 in each group?

3.        Blood sample:

a.        “Amount (size/ volume): from 2 ml “ what is the maximum amount of blood drawn?

b.       “Frequency: every 10 seconds “

4.        How many times will the study “drug” be administered?

5.        How long after the drug administration will the blood be drawn?

6.        “COS “ what are the expected side effects of its use, and what is the rate of occurrence of these side effects?

Comment to the Committee

Informed consent form:

N/A

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