National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Effect of Empagliflozin on manganese-induced Parkinson’s disease in rats

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

 To get an effect size (f) of 3.1 and a study power of 90% (1- error probe), each study group will be assigned twelve rats. This number will be needed to prove that the effect of the drug on the treatment group is different from the effect on the normal control group.

The sample size calculation recommended 12 rats per group, you will use 6 only?

Comment to the Committee

Informed consent form:

N/A

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