National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Formulation of sulfonamides loaded cream for topical use to treat skin candidiasis

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

·         Duration of the study: not 7 days

because the duration of the study

include all steps of the experiment

·         The protocol was not reviewed by scientific reviewing committee

·          

·         Fund amount: Self ?

·         Background: It is very short and contains only one reference

·         Procedure in Details: Organs may not be uniformly colonized by C. albicans, and so it is recommended that fungal burden and histology be performed on separate, whole organs.( write skin not organs )

·         Gantt Chart : It does not contain any information about the experiment

·          List of References :only  one reference

·         Agent / Substance : it is written

·         Drag Analgesic: thiopental sodium 20 mg / kg I.P, just before sacrifice .But in the procedure in details ,it is written rats will be subjected to light ether anesthesia ,also  Rats will be prepared by anesthetizing with an intraperitoneal injection of ketamine (80–100 mg/kg)

·         Confirmation of Death in Animals: it is written Yes, animal death will be confirmed by the examination of the eye reflex and color.Although, The animals will be subjected to decapitation

·         Animal disposition: It is written dead bodies will be incinerated in the National Research Centre incinerator . Although , the National Research Centre  does ont have  an incinerator .

العنوان العربى:

تركيبة السلفونامايد في كريم للاستخدام الخارجى  لعلاج كانديدا الجلد

Comment to the Committee

العنوان العربى:

تركيبة السلفونامايد في كريم للاستخدام الخارجى  لعلاج كانديدا الجلد

·         Duration of the study: not 7 days because the duration of the study include all steps of the experiment

·         The protocol was not reviewed by scientific reviewing committee

·          

·         Fund amount: Self ?

·         Background: It is very short and contains only one reference

·         Procedure in Details: Organs may not be uniformly colonized by C. albicans, and so it is recommended that fungal burden and histology be performed on separate, whole organs.( write skin not organs )

·         Gantt Chart : It does not contain any information about the experiment

·          List of References :only  one reference

·         Agent / Substance : it is written

·         Drag Analgesic: thiopental sodium 20 mg / kg I.P, just before sacrifice .But in the procedure in details ,it is written rats will be subjected to light ether anesthesia ,also  Rats will be prepared by anesthetizing with an intraperitoneal injection of ketamine (80–100 mg/kg)

·         Confirmation of Death in Animals: it is written Yes, animal death will be confirmed by the examination of the eye reflex and color.Although, The animals will be subjected to decapitation

·         Animal disposition: It is written dead bodies will be incinerated in the National Research Centre incinerator . Although , the National Research Centre  does ont have  an incinerator .

Informed consent form:

N/A

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