National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

The Potency of Novel Sulfadiazine-Based Azodyes for Treatment of Bacterial Infection and Wound Healing Enhancement in Streptozotocin-Induced Diabetic Rats

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

·         This research has scientific importance and value in the treatment of the bacterial infections and wound healing in diabetic patients.

·         The research has scientific approval to conduct  the research from the Faculty of Science and Ain Shams University .

·         There is no clear disclosure of the source and value of the fund.

·         The role of the researcher should be more clearly explained

·         Duration of study: not one month  because the duration of the study include all steps of the experiment.

·         Research Team Information and the process he/ she is responsible: In the experiences of the research team sometimes it is written briefly and another times is written as CV.

·         Procedure in Details : The type of bacteria which used in the study are vary in written then will be infected with about 105 CFU/mL of the Streptocococcus pyogenes or Pseudomonas aeruginosa bacteria,but in the experimental design Group 1 infected with Staphylococcus aureus Group 2 infected with Enterococcus and in Describe all procedures on the animals; The wounds will be infected with about 10⁵ CFU/mL of the Streptococcus pyogenes,( Which is correct ? please explain.

·         Sample size and groups and in flow chart : The groups are written differently than they written in the animal experiment  .

فى اقرار الباحثين : عدد الحيوانات 42  ولكنه فى تصميم التجربة عدد الحيوانات 30

Comment to the Committee

·         This research has scientific importance and value in the treatment of the bacterial infections and wound healing in diabetic patients.

·         The research has scientific approval to conduct  the research from the Faculty of Science and Ain Shams University .

·         There is no clear disclosure of the source and value of the fund.

·         The role of the researcher should be more clearly explained

·         Duration of study: not one month  because the duration of the study include all steps of the experiment.

·         Research Team Information and the process he/ she is responsible: In the experiences of the research team sometimes it is written briefly and another times is written as CV.

·         Procedure in Details : The type of bacteria which used in the study are vary in written then will be infected with about 105 CFU/mL of the Streptocococcus pyogenes or Pseudomonas aeruginosa bacteria,but in the experimental design Group 1 infected with Staphylococcus aureus Group 2 infected with Enterococcus and in Describe all procedures on the animals; The wounds will be infected with about 10⁵ CFU/mL of the Streptococcus pyogenes,( Which is correct ? please explain.

·         Sample size and groups and in flow chart : The groups are written differently than they written in the animal experiment  .

فى اقرار الباحثين : عدد الحيوانات 42  ولكنه فى تصميم التجربة عدد الحيوانات 30

Informed consent form:

N/A

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