National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Ameliorative Potential of Peanut Protein on Statin-Induced Testicular Histopathological Alterations, Hormonal Imbalance, and Semen Quality in Male Rats

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

تعديل العنوان العربى

االقدرة التحسينية لبروتين الفول السوداني على التغيرات الباثولوجية  في الخصية الناتجة عن المستحث بالستاتين، واختلال التوازن الهرموني، وجودة السائل المنوي لدى ذكور الفئران

·         The protocol was not reviewed by scientific reviewing committee

·         Primary Objective is unclear ,and the name of the plant used  as well as the bioactive constitution   should be written

·         Back ground : many paragraphs written without references  and at the end the text is cut off

·         Procedure in details is very brief and without details . In addition to writing  histopathological   examination not histology  examination

·         Sample size calculate  written as pilot study

·         Treatment by force feeding the extract daily is written in Gantti chart for one month but in flow chart is written 2 weeks which is right

·         Drug /agent . write the name of plant

·         In severity of pain in animal s written as no pain although the following question mention and describe the anticipated pain Frequency: The pain of the syringe during injection is used to prepare the model, treatment is administered orally, and cervical dislocation is at the end of the experiment

·         Experimental procedures not clear

 

Comment to the Committee

Protocol Title in English:

Ameliorative Potential of Peanut Protein on Statin-Induced Testicular Histopathological Alterations, Hormonal Imbalance, and Semen Quality in Male Rats

تعديل فى العنوان العربى

االقدرة التحسينية لبروتين الفول السوداني على التغيرات الباثولوجية  في الخصية الناتجة عن المستحث بالستاتين، واختلال التوازن الهرموني، وجودة السائل المنوي لدى ذكور الفئران

·         The protocol was not reviewed by scientific reviewing committee

·         Primary Objective is unclear ,and the name of the plant used  as well as the bioactive constitution   should be written

·         Back ground : many paragraphs written without references  and at the end the text is cut off

·         Procedure in details is very brief and without details . In addition to writing  histopathological   examination not histology  examination

·         Sample size calculate  written as pilot study

·         Treatment by force feeding the extract daily is written in Gantti chart for one month but in flow chart is written 2 weeks which is right

·         Drug /agent . write the name of plant

·         In severity of pain in animal s written as no pain although the following question mention and describe the anticipated pain Frequency: The pain of the syringe during injection is used to prepare the model, treatment is administered orally, and cervical dislocation is at the end of the experiment

·         Experimental procedures not clear

 

Informed consent form:

N/A

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