National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Protective Effects of Benzoic and Salicylic Acids Against Ochratoxin A (OTA)-Induced Toxicity and Ochratoxicosis Symptoms in Female Mice

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

Protective Effects of Benzoic and Salicylic Acids Against fungal  Ochratoxin A (OTA)-Induced Toxicity and Ochratoxicosis Symptoms in Female Mice

التأثيرات الوقائية لأحماض البنزويك والساليسيليك ضد السمية الناجمة عن سم  فطر الأوكراتوكسين وأعراض التسمم بالأوكراتوكسين في إناث الفئران

 

·         The protocol was not reviewed by scientific reviewing committee

·         Fund amount is not mentioned

·         Co investigator  1&3 the institute and department are not  mentioned

·         Primary Objective and Secondary Objectives are the same

·         Total Number of animals in the experiment is very small (12)

·         No mention the preparation and safety depose of the fungus

·         Gantt chart : the start of experiment is 1/5/2025- 1/5/2026

·         Surgical procedure and surgical consideration are written in more  details ,although  the mice will be sacrificed by cervical decapitation. Liver, kidney, and heart tissues will be collected for histopathological examination

·         In general, the writing in the protocol should be in the  future  

 

 

Comment to the Committee

Protective Effects of Benzoic and Salicylic Acids Against fungal  Ochratoxin A (OTA)-Induced Toxicity and Ochratoxicosis Symptoms in Female Mice

التأثيرات الوقائية لأحماض البنزويك والساليسيليك ضد السمية الناجمة عن سم  فطر الأوكراتوكسين وأعراض التسمم بالأوكراتوكسين في إناث الفئران

 

·         The protocol was not reviewed by scientific reviewing committee

·         Fund amount is not mentioned

·         Co investigator  1&3 the institute and department are not  mentioned

·         Primary Objective and Secondary Objectives are the same

·         Total Number of animals in the experiment is very small (12)

·         No mention the preparation and safety depose of the fungus

·         Gantt chart : the start of experiment is 1/5/2025- 1/5/2026

·         Surgical procedure and surgical consideration are written in more  details ,although  the mice will be sacrificed by cervical decapitation. Liver, kidney, and heart tissues will be collected for histopathological examination

·         In general, the writing in the protocol should be in the  future  

 

 

Informed consent form:

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