National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Formulation and biological evaluation of origanum majorana essential oil loaded nanoemulsion for treatment of Alzheimer

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1) تعديل العنوان باللغه العربيه الى  صياغة وتقييم الاداء البيولوجى للمستحلب النانونى المحمل بالزيت العطري  لنبات اوريجانم ماجورانا  لعلاج  الزهايمر 

2) The Text should be written in  the Future tense and not the Past tense. 3)Please modify the start Date(1/3/2024). 4)Complete the Affiliation of the Teamwork (Depart._Inst.) 4)Please clarify if,the essential oil will be prepared from the fresh plant ,in this case, the plant must be authenticated , or it has been bought from the Market, in this case , the origin must be clarified. 5)The dose of the essential oil (200 mg/kg),orally,is not documented by acute toxicity and LD50 , or published reference.Reference (3) mentioned in the text as a document (Records Nat.Prod.,2015,9,(3),419. does not confirm the suggested dose  (noting that ,high dose of essential oil ,in general,may produce side effects) 6)Gantt and Flowcharts are missing ,as well as,  the document concerning Conflict of interest.

Comment to the Committee

Informed consent form:

N/A

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