National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

A Novel Nanotherapeutic Protective Approach Using Chitosan-Coated Biosynthesized Selenium Nanoparticles Against Gentamicin-Induced Hepatorenal Damage in a Rat Model

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1)Please complete the Affiliation of the PI and the Teamwork.                                           2) In the Experimental Design ( group 5 of rats) Please mention the reference or our previous toxicological results which confirm  the safety on using  ,the novel preparation,( chitosan coated Senanoparticles {Ch/SeNPs} ) in a dose of 10 mg/kg b.wt/orally for 14 days,especially that Se is toxic  in large doses.                     3)More details are required  to clarify the Flowchart diagram.

Comment to the Committee

Informed consent form:

N/A

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