National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Pecan oil vesicles alleviates the ovariectomy-induced osteoporosis in rats: Involvement of OPG/RANKL

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1) تعديل العنوان باللغه العربيه الى : دراسة تاثير الحويصلات المحمله بزيت البقان فى الوقايه من هشاشة العظام المستحدثه عن طريق استئصال المبايض فى الجرذان دور   OPG/RANKL                   2)English Title:Study of the Protective Effect of Pecan oil Vesicles against Ovariectomy Induced Osteoporosis in Rats:OPG/RANKL . 3)Please complete the Affiliation of PI (Department & Institute ) 4) Complete in the Procedure the Data concerning the Pecan plant ( name ( Genus,species ,Family) ,origin ,used organ,if the oil will be prepared ,method of extraction ,LD50 of the oil or  previous  biological studies  which confirm the efficacy & safety  on using the oil in a dose equal 2.5 ml/kg/b.wt. 5)Please correct in  the part (substance & agent) the  dose of Pentobarbital sodium 3ml /kg and confirm with reference. 6)Complete the Gantt Chart by clarifying the type of administration which will be given during the 12 weeks.

Comment to the Committee

Informed consent form:

N/A

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