National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

The effect of carvacrol nanoemulsions in treating dry eye induced surgically in rats

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1--Arabic title need change to:

تأثير مستحلبات كارفاكرول النانوية في علاج جفاف العين المستحث جراحيا في الفئران

2-The funding amount was not specified.

3. The contribution of the fifth co-author is the preparation of the extract; however, the authors did not mention the name of the plant or the method of extraction. They stated that they will use a commercial carvacrol nanoemulsion (CAR@phyCub-CHS) in four different doses. It is crucial to clarify whether this is indeed a commercial nanoemulsion or if they plan to extract it from a plant (and if so, they should specify the plant's name and the extraction method). If it is a commercial product, the authors must provide the product's name and the name of the company.

4. The authors did not specify the analyses they will conduct on blood and tissue samples, nor did they provide details about the methodologies they will use for these analyses.

 5. The duration of the in vivo experiments will be one month; however, the authors have not included any details regarding the analysis of blood and tissue samples.

 

Comment to the Committee

Informed consent form:

N/A

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