National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Protective effect of zinc and Alpha-lipoic acid against olanzapine-induced metabolic syndrome andreproductive dysfunction in rats.

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1-The applicant wrote{fifty female and male wistar adult rats(10 rats per group)"i.e 5 groups while he divided the rats into 6 groups

2--He didnt add an important group which is Olanzepine+zinc+lipoic acid(Both the protective agents in one group)

3-He didnt mention the clinical and the pathological investigations that will be carried out e.g hormonal assay

Comment to the Committee

1-The applicant wrote{fifty female and male wistar adult rats(10 rats per group)"i.e 5 groups while he divided the rats into 6 groups

2-He didnt add an important group which is Olanzepine+zinc+lipoic acid(Both the protective agents in one group)

3-He didnt mention the clinical and the pathological investigations that will be carried out e.g hormonal assay

Informed consent form:

N/A

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