National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

“Efficacy Evaluation of Polysaccharide-Based Hydrogels Loaded with Novel Sulfathiazole Derivatives in Wound Healing of Diabetic Rats Infected with Multidrug-Resistant Bacteria”

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1. In role/tasks of the principle investigator, the author explained the aim of the study, but the requirement is to specify the roles and tasks will undertake during the study.

2. Duration of the study is not specified.

3. Fund amount is not specified.

4. The background section lacks supporting references.

5. The procedure section inconsistently uses verb tenses: methods are described in the future tense, whereas other parts of the same section use the past tense.

6. Diabetes will be induced in overnight fasted rats by a single intraperitoneal injection of a freshly solution of STZ (Provide full name).

7. The file named "Gantt chart" currently indicates a Conflict of Interest file. Please design and upload an actual Gantt chart showing the project timeline instead, and replace the existing file.

8. In flow chart, Rats are divided into six groups while in procedures they are divided into three groups. Which section is accurate — the flow chart (6 groups) or procedures (3 groups)? Pls revise and correct the wrong.

Comment to the Committee

Informed consent form:

N/A

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