National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Phyto- and Biochemical Study on Garden Cress (Lepidium sativum Linn.) Seeds Extracts: in Vitro and in Vivo Studies

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

The protocol needs amendments:

Comment to the Committee

The protocol needs amendments:

1- The researcher explained that the study will start in July 2024.

2- The principal investigator wrote that the protocol had not been reviewed.

3- The researcher did not explain how to obtain human liver cells (HEPG-2), colon cancer cells (CACO-2), and lung cancer cells (A549).

4- The Median lethal dose (LD50) study needs clarification because the number of mice that will be used is more than what the principal researcher indicated.

5- There is still repetition in many parts of the protocol.

6- In the form of good care of animals used in research, the researcher must list the handling of animals only (in vivo) and not the cells in the laboratory (in vitro).

Informed consent form:

N/A

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