National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Preparation and evaluation of an oral nano formulation for marmesin as a natural therapy intended for protection against doxorubicin-induced liver toxicity in rats

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

The protocol needs minor modifications:

Comment to the Committee

The protocol needs minor modifications:

العنوان العربى: تبديل كلمة صياغة بكلمة تركيبة وتبديل كلمة فئران بكلمة جرذان

2- The amount of blood drawn from each animal has not been determined.

3- The source of marmesin is not clear, will it be purchased or will it be extracted from the plant?

4- What type of nano is used that will increase the solubility of marmesin

5- Disposal of animals : It was written that they would be placed in an incinerator, even though the center does not have an incinerator.?

Informed consent form:

N/A

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