National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Unlocking the Anticancer Mechanisms of Glycyrrhiza glabra: Metabolic Profiling, In Vivo Validation, and Computational Docking Insights

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1- The methodology is written in the past tense. Please explain why?

2- The age of the mice "approximately" what is the allowed days / weeks window for the age?

3- Reducing/mitigating the risk is not sufficient and does not make sense. The mice will be injected with cancer cells, this is a risk in itself.

4- Justify using female mice

5- Question: Group1 are mice who did not receive any cancer cells nor any treatment? Will this group be euthanized as well?

Comment to the Committee

I am sorry for the delay

Informed consent form:

N/A

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