1-The title includes abbreviations (NRF2/NF-κB, PI3K/AKT, and NOX-2/NLRP3) that need to be explained in detail.

2-The experiment is scheduled to last 7 months in the Gantt chart, but it states 2 months.

3-The methodology written should be revised to be presented in the present tense.

4-The authors stated that the project had not been revised, despite having signatures from the head of the department and the dean of the institute on Form 90.

5-They wrote that the fund will be self, and in another application is 20000 LE, they must add it to the application

6- The prostate cancer cells (PC3 cells) were obtained from the American Type Culture Collection (ATCC). Was this material purchased, or is it available through collaboration?

7- What is the Azodye used in PC3 cells tissue culture at different doses, including the company and its role in cancer treatment?

8-The abbreviations SO and SD are not commonly known; they should be clearly defined to understand their role in treating prostate enlargement.

9- The experiments are 7 groups, while they wrote that the number of animal are 10/group, then 8/groups it must be clear.