National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

The Protective Impact of Neem Seed, Leaf and Flower Extracts on Methotrexate‑Induced Lung Toxicity: Mitigating TGF-Β/P38mapk and NFκB/NRF2-SOD1 Signaling Pathways

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

PI Name: Asmaa Abd El hamid

The fund amount (please wright an approximately value)

The signature in the Approval letter ( 90-1-pdf ) إمضاء عميد المعهد

The dose of normal saline to be injected intraperitoneally on day 7 is not specified; only the concentration of normal saline is mentioned. 

The origin and Authentication of the plant in the preparation of crude extracts

Please mention the precautions that will be followed to minimize health risk of MTX to humans and / or animals.

Add the missing equation concerning the extraction yield %.4 (in the experimental details)

Comment to the Committee

PI Name: Asmaa Abd El hamid

The fund amount (please wright an approximately value)

The signature in the Approval letter ( 90-1-pdf ) إمضاء عميد المعهد

The dose of normal saline to be injected intraperitoneally on day 7 is not specified; only the concentration of normal saline is mentioned. 

The origin and Authentication of the plant in the preparation of crude extracts

Please mention the precautions that will be followed to minimize health risk of MTX to humans and / or animals.

Add the missing equation concerning the extraction yield %.4 (in the experimental details)

Informed consent form:

N/A

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