National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Effect of Cilostazol on cisplatin-induced cardiotoxicity and nephrotoxicity in rats

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

Non

Comment to the Committee

1- Euthanasia Method and Timing: It's crucial to specify the euthanasia method to ensure the humane treatment of the animals. Additionally, the timing of euthanasia should be clearly defined to avoid unnecessary suffering.
2- Cisplatin Administration Schedule: The administration schedule for cisplatin in the third and fourth groups needs to be specified to ensure accurate dosing and to avoid potential adverse effects.
3- Cilostazol Dosage and Route of Administration: The daily dosage and route of administration of Cilostazol over the 14 days in the third and fourth groups must be clearly defined to ensure consistent treatment and accurate data collection

Informed consent form:

N/A

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