National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Protective effect of zinc and Alpha-lipoic acid against olanzapine-induced metabolic syndrome andreproductive dysfunction in rats.

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1- Affiliations, experience and roles for Co-Is are missing

2-Objectives are not well formulated

3- There is no Null hypothesis, although the sample size calculation is written to reject the null hypothesis

4- Source mentions mature-male, while the methodology mentions females and males. Please correct the discrepancy.

5- The Procedures section does not mention what will be done after the treatment.

6- Animal disposition answer is euthenesia and not disposition.

Comment to the Committee

Comments about the website

1-Once the comments view is open it cannot be closed to view all the protocol.

2-The comments cannot be saved for a later session

As for the protocol, it looks like a manuscript. Not sure if it was already performed or not, I am not sure.

Informed consent form:

N/A

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