National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Metabolomics analysis versus uterine hyperplasia and ovarian cancer rat model: liposomal resveratrol therapeutic approach

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1-     Justification of animal use should justify why this type of animals was specifically used.

2-     Justification of the number of animals is missing.

3-     Sample size calculation is missing.

4-     Justification for not doing a pilot study and the 2 Rs are not clear.

5-     Pain: Isn’t blood drawing considered painful for the animals?

Comment to the Committee

Informed consent form:

N/A

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