MREC Reviewer Comment
Protocol Title
Completely satisfied and informative data
Comments to the applicant
Duration of the study: he mention at 1 dec. 2024 although he the study will take 12 weeks
The protocol was reviewed by scientific reviewing committee: he mention no although he attach 90
Sample size study power (we need the equation)
Is Euthanasia part of the study design (he mention no although he will euthanize the rats before cervical dislocation
Describe the anticipated pain or distress for animals; describe how pain or distress will be monitored
Correction of: List who will monitor or observe animals and Indicate the schedule of monitoring (the answer of these questions are the same which is: All groups of rats will be anesthetized with xylazine and ketamine (20 and 50 mg/kg, i.p., respectively).
Correction what will be the method of disposal of dead animals (he mention following the rules approved by the ethical committee for disposal of dead animals).Occupational Safety and Health Committee
Comment to the Committee
Duration of the study: he mention at 1 dec. 2024 although he the study will take 12 weeks
The protocol was reviewed by scientific reviewing committee: he mention no although he attach 90
Sample size study power (we need the equation)
Is Euthanasia part of the study design (he mention no although he will euthanize the rats before cervical dislocation
Describe the anticipated pain or distress for animals; describe how pain or distress will be monitored
Correction of: List who will monitor or observe animals and Indicate the schedule of monitoring (the answer of these questions are the same which is: All groups of rats will be anesthetized with xylazine and ketamine (20 and 50 mg/kg, i.p., respectively).
Correction what will be the method of disposal of dead animals (he mention following the rules approved by the ethical committee for disposal of dead animals).Occupational Safety and Health Committee
