National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Gelatin grafted with Poly Bromo Phenyl Derivative Attenuates Potassium Dichromate Toxicity by Regulating the VEGF1–GPX4/SOD1–NRF2/HO-1 Signaling Axis in Rats

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

Protocol Title in English:  Gelatin grafted with Poly Bromo Phenyl  Derivative Attenuates Potassium Dichromate Toxicity by Regulating the VEGF1–GPX4/SOD1–NRF2/HO-1 Signaling Axis in Rats

Protocol Title in Arabic :

الجيلاتين المعالج بمشتق البولي برومو فينيل يُخفف من سمية ثنائي كرومات البوتاسيوم عن طريق تنظيم محور إشارات VEGF1–GPX4/SOD1–NRF2/HO-1 في الفئران

PI Name: Mona Samir

Comments

·         The general benefit of research : To discover a new anti-potassium dichromate drug from a natural source

·         Write the name of the institute and department in the principal investigator  data

·         Duration of study is written 2 months  but in gantti chart is design as 10weeks

·         The protocol not reviewed by scientific reviewing committee

·         Undefined fund amount

·         Please check the total number of animals forty or fifty it is written forty in  the species and common name ,total number  while it is written in fifty in Experimental protocol , Justification of Animal Use, Species – Specific Consideration and Justification of animal number

·         In severity of pain in animal s written as no pain but it is written mild pain

·          Drag Analgesic  and the dose not have written but Frequency Analgesic: daily Route of Administration Analgesic: oral

·         Gantt and Flowcharts as the same

·          In what will be the method of disposal of dead animals write how to disposal them

·          

Comment to the Committee

Protocol Title in English:  Gelatin grafted with Poly Bromo Phenyl  Derivative Attenuates Potassium Dichromate Toxicity by Regulating the VEGF1–GPX4/SOD1–NRF2/HO-1 Signaling Axis in Rats

Protocol Title in Arabic :

الجيلاتين المعالج بمشتق البولي برومو فينيل يُخفف من سمية ثنائي كرومات البوتاسيوم عن طريق تنظيم محور إشارات VEGF1–GPX4/SOD1–NRF2/HO-1 في الفئران

PI Name: Mona Samir

Comments

·         The general benefit of research : To discover a new anti-potassium dichromate drug from a natural source

·         Write the name of the institute and department in the principal investigator  data

·         Duration of study is written 2 months  but in gantti chart is design as 10weeks

·         The protocol not reviewed by scientific reviewing committee

·         Undefined fund amount

·         Please check the total number of animals forty or fifty it is written forty in  the species and common name ,total number  while it is written in fifty in Experimental protocol , Justification of Animal Use, Species – Specific Consideration and Justification of animal number

·         In severity of pain in animal s written as no pain but it is written mild pain

·          Drag Analgesic  and the dose not have written but Frequency Analgesic: daily Route of Administration Analgesic: oral

·         Gantt and Flowcharts as the same

·          In what will be the method of disposal of dead animals write how to disposal them

·          

Informed consent form:

N/A

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