National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Purslane Leaf Extract: A Novel Therapeutic Approach to Mitigate 4-(Methylnitrosamino)-1-(3-pyridyl)-1-buta-4 None (NNK)-Induced Testicular Histopathological Alterations and Hormonal Imbalances in Male Rats.

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

1)تغيير الجزء الاول من العنوان باللغة العربية الى  مستخلص اوراق نبات الرجلة   :  دراسة لنهج علاجى جديد_____ وكذلك فى العنوان باللغة الانجليزية الى                                                         Purslane Plant Leaf Extract: Study of a Novel Therapeutic Approach___.                                                                                                               2)Please mention the role of PI 3)Affiliation of the Teamwork                    4)The study type is Medicinal Plants 5)Please describe the procedure in details including  origin of the plant , its authentication by Taxonomist,cytotoxicity assay,origin of cell lines and NNK. 6)The protocol involves the use of toxic and carcinogenic substances as  cell lines and NNK ,Please mention the precautions that will be followed to minimize health risk to humans and / animals. 7)clarify the type of extract ( ether in the procedure and alcoholic in drug agent  ? )                  8)Mention the reference concerning the dose of NNK (1.5 mg/kg b.wt) 9)Please specify the organs and tissues in the part of (collection of biological samples).

Comment to the Committee

Informed consent form:

N/A

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