MREC Reviewer Comment
Protocol Title
The Protective Impact of Neem Seed, Leaf and Flower Extracts on Methotrexate‑Induced Lung Toxicity: Mitigating TGF-Β/P38mapk and NFκB/NRF2-SOD1 Signaling Pathways
Completely satisfied and informative data
Needs Explanation
Comments to the applicant
Please complete the followings; 1)The signature in the Approval letter ( 90-1-pdf ) 2)Origin and Authentication of the plant. 3)in the preparation of crude extracts Please add the missing equation concerning the extraction yield %.4)The Protocol involves th use of Methotrexate ,in a toxic dose ,please mention the precautions that will be followed to minimize health risk to humans and / or animals .
Comment to the Committee
Informed consent form:
N/A
