MREC Reviewer Comment
Protocol Title
Completely satisfied and informative data
Comments to the applicant
Kindly add the fund amount
Reduce amount of blood to 3 cc if possible
Comment to the Committee
Integrated analysis of ST6GAL1 gene expression and sialic acid levels in Familial Mediterranean Fever.
Protocol Title in Arabic :
ومستويات حمض السياليك في حمى البحر الأبيض المتوسط العائلية ST6GAL1تحليل متكامل للتعبير الجيني
Fund amount: 0
Kindly add the fund amount
Aim: Investigate the concentration of Sialic acid, IL-1β and IL-6 in serum. 2- Investigate the expression pattern of ST6GAL1, IL-1β and IL-6 genes. Illustrating the role of sialic acid, ST6GAL1, IL-1β and IL-6 on clinical phenotype of Familia Mediterranean Fever (FMF) patients and the expression of causative gene of FMF
Five ml of whole blood:
amount of blood asked to reduce
Sample size is ok; Fifty FMF patients with homozygous and heterozygous MEFV mutation. B- Control group: Fifty healthy normal controls of matching age and sex to the studied patient.
Gantt Chart is ok
Flow chart is the same as Gantt chart
موذج-الموافقة-المستنيرة
