National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Investigating the anti-arthritic activity of quercitrin and naringenin in a model of carrageenan-induced arthiritis in rats

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

-تعديل العنوان العربى

دراسة النشاط المضاد للالتهاب للكيرسيتين و النارينجينين في نموذج لالتهاب المفاصل المستحث في الجرذان باستخدام الكاراجينان

- Quercetin Not quercitrin (change it in all the proposal)

- Fund amount not specified
- While it is written that Naringenin and quercitrin will be purchased from (EGA Chemie, Germany), one member of the research team is specialized in phytochemistry, so what is his role?
-It is written “sterile 1% carrageenan”, how will it be sterilized?
- It is written that: group 1: normal control rats will receive 8 intra-articular injections of 0.1 mL saline, and Group 2: positive control (carrageenan) group: rats will receive 8 intra-articular injections of 0.1 ml of sterile 1% carrageenan why 8?
- Mention the source of glucosamine
-Revise the procedure of Histopathological examination, as you may need to perform decalcification before doing the normal procedure.
-Sometimes it is written that the study will include thirty adults male Wistar albino rats, and in other parts 48, please correct.
 

Comment to the Committee

Informed consent form:

N/A

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