National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Therapeutic Potential of Frankincense Oleo-gum resin for Management of Dentine Hypersensitivity: A Scanning Electron Microscope Survey

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

The background section is insufficient and requires further elaboration. More comprehensive information should be provided regarding both Gluma and frankincense, including:
Their previous or current applications in dental practice.
Reported advantages and disadvantages based on published literature.
Any clinical or in vitro evidence supporting their use in dentin hypersensitivity management.
In the methodology section, the exact number of teeth to be used in the study has not been clearly stated. The source of the extracted teeth should also be mentioned, including:
The institution or department providing the samples.
Confirmation that informed consent will be obtained from donors.
The concentration or composition of both Gluma and frankincense is not specified:
Justification should be provided for the selected preparation and dosage, ideally supported by preceding scientific studies or preliminary pilot data.
The laser parameters (e.g., wavelength, power, duration, mode) are provided, but the rationale for selecting these parameters is not discussed. The proposal should:
Cite previous studies that used similar laser settings for dentinal tubule occlusion or DH management.
Ensure that the parameters are clinically relevant and safe for dentin structure.

Comment to the Committee

Informed consent form:

Needs Modification

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