National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Fabrication of Carboxymethyl Cellulose/PVA-Sulfonamide Composite for the Amelioration of Benign Prostatic Hyperplasia in Rats via Modulating NRF2/NF-κB, PI3K/AKT, and NOX-2/NLRP3 Pathways

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

Please answer these comments clearly.

Calculating the sample size: You did not explain how to calculate the sample size, nor did you provide the reference used in this calculation??

 When asked whether human biological samples would be imported into Egypt, the answer was no, although she did say that prostate cancer cells (PC3) would be imported from the American group.??? where will it be purchased from?

Also, please revise the proposal according to the comments and not only through a reply to the comments seperatly.

Comment to the Committee

Informed consent form:

Waiver

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