·         In Background, the sentence is tailed with the reference "El-Hagrassi et al. 2022", showed that 45 compounds and 29 phenolic compounds, respectively, I think something is missing, 45 compounds for what?

·         In Procedures:

1-      The source of the plant is not provided.

2-      In experimental animals, groups 3 and 4 indicate the same meaning "the mice will be treated with low dose of plant extract after infecting with Cryptosporidium oocysts. Also the low dose and its frequency are not detected.

3-      The participants will use serum and intestine from mice for biochemical markers and histopathological examination, respectively, but they did not explain how to deal with the animals to obtain the blood and intestine.

·         The text in the two headlines "1. Have You Considered Pilot Studies, 2. Did Three Rs Determine Any Possible Reduction?" are not relevant.

The text is not relevant to this headline " What Criteria, Appropriate To The Species, Will Trigger The Decision To End The Study, Stop The Procedure, Or Humanely Euthanize An Animal Before The Experimental Objective Is Achieved