National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Cytoprotective effect of Morus nigra against ethanol-induced gastric ulcer in rat model.

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

You reported that the fund amount will be 10 (Do you mean ten thousand Egyptian Pounds?).

It's essential to outline the specific responsibilities of co-investigators in the study.

The acute toxicity study (LD50) will involve dividing 15 male Wistar albino rats into three groups, each receiving a different dose (100, 150, or 200 mg/kg body weight) of the plant fraction. To ensure clarity, please specify the plant source, the part of the plant used, and the nature of the fraction (e.g., ethanolic extract, aqueous extract, etc.).

The peptic ulcer model experiment should specify:

1. The dose of the plant extract used.

2. The amount of absolute ethanol administered to groups 3, 4, and 5.

3. The dose of ranitidine used in group 5.

 

The Gantt and flowchart files were uploaded incorrectly, with the Gantt chart labeled as the flowchart and vice versa.

Comment to the Committee

Informed consent form:

Waiver

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