National Research Centre

Medical Research Ethics Committee

MREC Reviewer Comment

Protocol Title

Development and evaluation of smart nanocarrier for Egyptian plant extract to tackle certain cancer cell lines”

Completely satisfied and informative data

Needs Explanation

Comments to the applicant

The protocol needs modifications.

Comment to the Committee

The protocol needs modifications.

1- The title: Whether Arabic or English, it lacks the specification of the plant type and the type of cancer cells.

2- Regarding the Fund amount: The student did not write the fund amount, even though it is funded by the center and the value is known.

3- The scientific background is very brief and contains only 3 references.

4- The references in the background are unordered (starting with number 1, then 2, then 13)

5- The student mentioned that the skin permeability test will be conducted on mice (she did not mention the number), then the irritation test will be conducted on rats (24 rats), then the anti-cancer activity test will be conducted on mice (12 mice). In other parts, the student mentioned that the animals are also rabbits (Which leads to great confusion)

6- The student mentioned that the number of animals is from 36 to 40 (clarification is required), and in other parts there are 48 animals.

7- The student mentioned that the animal’s sex is male and female, and in other parts, only males.

8- The student did not explain how she calculated the sample size

9- In the Gantt-Chart section, the student created an empty table.

10- In the flow-chart section, she put a page which is written: How to make a Flow Chart?

11- The student did not mention the type of cancer cells.

12- The student stated that dead animals will be sent to the center's incinerator (this is incorrect).

Informed consent form:

N/A

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